Protein quality control (PQC) senses and repairs misfolded and or unfolded proteins. However, if the repair fails, it degrades the terminally misfolded polypeptides through an intricate collaboration between molecular chaperones and targeted proteolysis. Proteolysis of damaged proteins is performed primarily by the ubiquitin-proteasome system (UPS). Macroautophagy (commonly known as autophag...
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